Ken Hirata Selected Research

N- pip- phenylalanine- homophenylalanine- vinyl sulfone phenyl

1/2018

Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis.

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Ken Hirata Research Topics

Disease

5	Amebiasis (Amoebiasis) 05/2016 - 01/2002
2	Stomach Neoplasms (Stomach Cancer) 02/2021 - 08/2015
2	COVID-19 01/2021 - 10/2020
2	Infections 01/2020 - 01/2012
2	Chagas Disease (American Trypanosomiasis) 01/2020 - 12/2017
2	Hemorrhage 04/2013 - 01/2012
2	Amebic Dysentery (Amoebic Dysentery) 06/2012 - 01/2012
2	Myocardial Ischemia (Ischemic Heart Diseases) 07/2003 - 04/2002
1	Fistula 02/2021
1	Disease Progression 01/2020
1	Acute Disease 01/2020
1	Toxoplasmosis 01/2018
1	Protozoan Infections 01/2018
1	Parasitic Diseases (Parasitic Disease) 12/2017
1	Parasitemia 12/2017
1	Cerebral Infarction 08/2015
1	Hematemesis 04/2013
1	Melena 04/2013
1	Anemia 04/2013
1	Amebic Liver Abscess 06/2012
1	Rheumatoid Arthritis 06/2012
1	Muscle Cramp (Cramp) 01/2012
1	Neoplasms (Cancer) 01/2012
1	Ulcer 01/2012
1	Inflammation (Inflammations) 06/2010
1	Diabetes Mellitus 01/2003
1	Ischemia 04/2002
1	Infarction (Infarctions) 04/2002

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 01/2020 - 06/2012
3	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 07/2007
3	Cysteine Proteases (Cysteine Protease)IBA 01/2012 - 01/2002
2	Cysteine Proteinase InhibitorsIBA 01/2021 - 10/2020
2	benzonidazole (benznidazole)IBA 01/2020 - 12/2017
2	divinyl sulfoneIBA 01/2018 - 06/2010
2	EnzymesIBA 12/2017 - 06/2010
2	Auranofin (Ridaura)FDA Link 05/2016 - 06/2012
2	AnticoagulantsIBA 08/2015 - 01/2012
1	posaconazole FDA Link 01/2020
1	N- pip- phenylalanine- homophenylalanine- vinyl sulfone phenylIBA 01/2018
1	CathepsinsIBA 01/2018
1	NifurtimoxIBA 12/2017
1	SterolsIBA 12/2017
1	GoldIBA 05/2016
1	2- hydroxylamino- 5- ethyl- 5- propylbarbituric acid (HB 2)IBA 04/2013
1	Antimicrobial PeptidesIBA 01/2012
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2012
1	CathelicidinsIBA 01/2012
1	Streptozocin (Streptozotocin)FDA Link 01/2003
1	salicylhydroxamic acid (SHAM)IBA 04/2002
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 04/2002

Therapy/Procedure

4	Therapeutics 12/2017 - 04/2002
1	Choledochostomy 02/2021
1	Gastrectomy 02/2021
1	Neoadjuvant Therapy 08/2015
1	Aftercare (After-Treatment) 07/2003
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 07/2003
1	Ligation 04/2002